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CosmoPAGE Pre-cast Gels
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  eChemShop - Chemical Reagents, Natural Compounds, Software, HPLC columns :: COSMOSIL Cholester *NEW*

    COSMOSIL Cholester *NEW*
View More Quality SILICA and ALUMINA Products

COSMOSIL Cholester*NEW*

COSMOSIL Cholester is a new silica based RP column which employs a cholestery
bonded phase. Cholester provides enhanced selectivity over traditional C18
materials and greater performance in separating isomers or other closely related
compounds. Cholester is ideal for method development and serves as an excellent
alternative to traditional C18 columns.

 

Material Characteristics: 

COSMOSIL Cholester
Silicagel high purity porous spherical silica
Average particle size 5?m
Average pore size approx. 120?
Specific surface area approx. 300m2/g
Stationary phase Monomeric Cholesteryl group
End capping treatment near-perfect treatment
Carbon content approx. 20%

 

Separation of Alkylbenzene (comparison with Hydrophobicity)

Cholester provides the same hydrophobicity as ODS and C30 columns.

 

 

Characteristics of separation

Aryl Halides (Relative strengths of nucleophiles : Methyl < Chlorine < Bromine)

Cholester is more selective for Aryl Halides

 

Planarity Selectivity (Planarity : o-Terphenyl < Triphenylene)

Cholester shows greater planarity selectivity.

 

Steroids like D Vitamins

Cholesteryl bonded groups are very rigid structures and offer improved separation
of compounds that are difficult to analyze with alkyl group bonded materials.

 

Diasteromers like Stilbenes

Cholester offers improved resolution of geometric isomers.

 

Position isomers like Chloroacetophenones and Terphenyls

Generally isomers of disubstituted benzene are difficult to separate with C18
because their structual and polar characteristics are veryb similar.
In these cases COSMOSIL Cholester works very well.

 
 
 
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