Details
Cholic Acid cholate Cholanic acid Cholalin Colalin Cholalic acid Cholsaeure
Source: Occurs in conjugation with glycine or taurine in bile of most vertebratesReference: Merck 13, 2223Reference:
THERAPEUTIC CATEGORY: Choleretic
Merck 13 Reference: Monograph Number: 0002223
Percent Composition: C 70.55%, H 9.87%, O 19.58%
Literature References: Occurs in conjugation with glycine or taurine in bile of most vertebrates. Extraction from beef bile: Wieland, Siebert, Z. Physiol. Chem. 262, 1 (1939); laboratory procedure: Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 360. Structure and synthesis: Fieser, Fieser, Steroids (Reinhold, New York, 1959).
Derivative Type: Monohydrate
Properties: Plates from dil acetic acid. Bitter taste with sweetish aftertaste. When anhydr, mp 198. [a]D20 +37 (c = 0.6 in alcohol). pK = 6.4. Not precipitated by digitonin. Soly at 15 in water 0.28 g/l; in alcohol 30.56 g/l; in ether 1.22 g/l; in chloroform 5.08 g/l; in benzene 0.36 g/l; in acetone 28.24 g/l; in glacial acetic acid 152.12 g/l. Sol in solns of alkali hydroxides or carbonates.
Melting point: mp 198
pKa: pK = 6.4
Optical Rotation: [a]D20 +37 (c = 0.6 in alcohol)
Therap-Cat: Choleretic.
InChIKey=BHQCQFFYRZLCQQ-OELDTZBJSA-N
C24H40O5 |
408.58 |
5.68 |
-5.35 |
0.79 |
4 |
5 |
4 |
4 |
11 |
5 |